N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity

Bioorg Med Chem Lett. 2004 Feb 9;14(3):787-91. doi: 10.1016/j.bmcl.2003.11.019.

Abstract

A series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure-activity relationship reveals that not only the two oxygens and amide hydrogen of sulfonamido group, but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Calcium / metabolism
  • Capsaicin / metabolism*
  • Cells, Cultured
  • Ganglia, Spinal / drug effects
  • Ligands
  • Molecular Structure
  • Neurons / drug effects*
  • Rats
  • Receptors, Drug / agonists
  • Receptors, Drug / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis
  • Sulfonamides / pharmacology*
  • Thiourea / analogs & derivatives
  • Thiourea / chemical synthesis
  • Thiourea / pharmacology*

Substances

  • Ligands
  • Receptors, Drug
  • Sulfonamides
  • Thiourea
  • Capsaicin
  • Calcium